Structure of PDB 3jcs Chain T

Receptor sequence

>3jcsT (length=154) Species: 5661 (Leishmania donovani)

THYSRKPQVSSKSAKAKVSDLRCHYKNTFETANVINGMPLRKAQQLYRQV
LAKTRCIPFKRYNGKIGRTAQAKEWGQTKGRWPRKSVVAMMSLLKNAEAN
AIEKGLDPNQMVIKHVQVDQAARMRRRTYRAHGRITPYMCSPCHVQLFMS
EKKE

3D structure

• PDB: 3jcs 2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
• Chain: T
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	T	T2 H3 R6 K16 K18 R23 H25 Y26 K27 F30 N37 R62 Y63 G65 K66 R82 N97 A100 N101 Q118 V119 R127 T129 R131 A132 H133	T1 H2 R5 K15 K17 R22 H24 Y25 K26 F29 N36 R61 Y62 G64 K65 R81 N96 A99 N100 Q117 V118 R126 T128 R130 A131 H132
BS02	rna	T	H25 K66 I67 G68 R69 T79 K80 R82 W83 R85 K86 R127 Y130 R131 I136 T137 P138 Y139 M140	H24 K65 I66 G67 R68 T78 K79 R81 W82 R84 K85 R126 Y129 R130 I135 T136 P137 Y138 M139
BS03	rna	T	Q46 Q50 T55 R56 R69 A71 Q72 K74 E75	Q45 Q49 T54 R55 R68 A70 Q71 K73 E74
BS04	rna	T	S5 K61 R62 D120 Q121	S4 K60 R61 D119 Q120

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:3jcs, PDBe:3jcs, PDBj:3jcs
• PDBsum: 3jcs
• PubMed: 27373148
• UniProt: A0A3S7WY02