Structure of PDB 2gk1 Chain T

Receptor sequence
>2gk1T (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
DSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPK
IQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLA
PGTIVEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKV
EPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSS
KDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYCN
3D structure
PDB2gk1 Crystallographic Structure of Human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of G(M2) Ganglioside Hydrolysis.
ChainT
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.52: beta-N-acetylhexosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NGT T E355 W424 Y450 D452 L453 W489 E491 E39 W108 Y134 D136 L137 W173 E175 BindingDB: Ki=190nM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563 beta-N-acetylhexosaminidase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2gk1, PDBe:2gk1, PDBj:2gk1
PDBsum2gk1
PubMed16698036
UniProtP07686|HEXB_HUMAN Beta-hexosaminidase subunit beta (Gene Name=HEXB)

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