Structure of PDB 8xsy Chain Sg

Receptor sequence

>8xsySg (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]

TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETN
YGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF
VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWV
SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVS
PDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA
TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAG
YTDNLVRVWQVTI

3D structure

PDB

8xsy Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

3.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Sg	N15 G61 H64 R100 K280	N14 G60 H63 R99 K279

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0005080	protein kinase C binding
GO:0005102	signaling receptor binding
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008200	ion channel inhibitor activity
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0030292	protein tyrosine kinase inhibitor activity
GO:0030332	cyclin binding
GO:0030971	receptor tyrosine kinase binding
GO:0035591	signaling adaptor activity
GO:0042169	SH2 domain binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043022	ribosome binding
GO:0045296	cadherin binding
GO:0051434	BH3 domain binding
GO:0060090	molecular adaptor activity

	Biological Process
GO:0001934	positive regulation of protein phosphorylation
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0006417	regulation of translation
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007369	gastrulation
GO:0010629	negative regulation of gene expression
GO:0016567	protein ubiquitination
GO:0017148	negative regulation of translation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030308	negative regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0031334	positive regulation of protein-containing complex assembly
GO:0032091	negative regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880	regulation of protein localization
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0042998	positive regulation of Golgi to plasma membrane protein transport
GO:0043065	positive regulation of apoptotic process
GO:0043473	pigmentation
GO:0043547	positive regulation of GTPase activity
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048511	rhythmic process
GO:0050765	negative regulation of phagocytosis
GO:0051302	regulation of cell division
GO:0051726	regulation of cell cycle
GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051901	positive regulation of mitochondrial depolarization
GO:0071333	cellular response to glucose stimulus
GO:0071363	cellular response to growth factor stimulus
GO:0072344	rescue of stalled ribosome
GO:0106070	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:1900102	negative regulation of endoplasmic reticulum unfolded protein response
GO:1903751	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO:2000114	regulation of establishment of cell polarity
GO:2000543	positive regulation of gastrulation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

	Cellular Component
GO:0001891	phagocytic cup
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005886	plasma membrane
GO:0015935	small ribosomal subunit
GO:0022627	cytosolic small ribosomal subunit
GO:0030425	dendrite
GO:0030496	midbody
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0044297	cell body
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular exosome
GO:1990630	IRE1-RACK1-PP2A complex
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8xsy, PDBe:8xsy, PDBj:8xsy
PDBsum	8xsy
PubMed	38942792
UniProt	P63244\|RACK1_HUMAN Small ribosomal subunit protein RACK1 (Gene Name=RACK1)

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