Structure of PDB 8xxn Chain Sf

Receptor sequence

>8xxnSf (length=67) Species: 9606 (Homo sapiens) [Search protein sequence]

YTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMAS
HFDRHYCGKCCLTYCFN

3D structure

PDB

8xxn Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

Chain

Resolution

3.6 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Sf	T87 K89 K90 N91 K92 H93 R95 K97 K99 A101 Y105 R118 V130 M132 A133 S134 H135 R138 Y140 G142 K143 T147	T3 K5 K6 N7 K8 H9 R11 K13 K15 A17 Y21 R34 V46 M48 A49 S50 H51 R54 Y56 G58 K59 T63

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0031386	protein tag activity
GO:0031625	ubiquitin protein ligase binding
GO:0046872	metal ion binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0016567	protein ubiquitination
GO:0019941	modification-dependent protein catabolic process

	Cellular Component
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0030666	endocytic vesicle membrane
GO:0031982	vesicle
GO:0032040	small-subunit processome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8xxn, PDBe:8xxn, PDBj:8xxn
PDBsum	8xxn
PubMed	38641729
UniProt	P62979\|RS27A_HUMAN Ubiquitin-ribosomal protein eS31 fusion protein (Gene Name=RPS27A)