Structure of PDB 8k2c Chain Sf

Receptor sequence

>8k2cSf (length=67) Species: 9606 (Homo sapiens) [Search protein sequence]

YTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMAS
HFDRHYCGKCCLTYCFN

3D structure

PDB

8k2c Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Sf	T87 K90 K92 H93 K94 R95 K97 K99 A101 Y105 V130 F131 M132 A133 H135 R138 Y140 G142 K143 C145 T147	T3 K6 K8 H9 K10 R11 K13 K15 A17 Y21 V46 F47 M48 A49 H51 R54 Y56 G58 K59 C61 T63
BS02	ZN	Sf	C121 C141	C37 C57

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0031386	protein tag activity
GO:0031625	ubiquitin protein ligase binding
GO:0046872	metal ion binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0016567	protein ubiquitination
GO:0019941	modification-dependent protein catabolic process

	Cellular Component
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0030666	endocytic vesicle membrane
GO:0031982	vesicle
GO:0032040	small-subunit processome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8k2c, PDBe:8k2c, PDBj:8k2c
PDBsum	8k2c
PubMed	38942792
UniProt	P62979\|RS27A_HUMAN Ubiquitin-ribosomal protein eS31 fusion protein (Gene Name=RPS27A)