Structure of PDB 8k2a Chain Sf

Receptor sequence

>8k2aSf (length=370) Species: 9606 (Homo sapiens) [Search protein sequence]

VARYPPIVASMTADSKAARLRRIERWQATVHAAESVDEKLRILTKMQFMK
YMVYPQTFALNADRWYQYFTKTVFLSGLPAALRAVACDCLLQEHFYLRRR
RRVHRYEESEVISLPFLDQLVSTLVGLLSPHNPALAAAALDYRCPVHFYW
VRGEEIIPRGHRRGRIDDLRYQIDDKPNNQIRISKQLAEFVPLDYSVPIE
IPTIKCKPDKLPLFKRQYENHIFVGSKTADPCCYGHTQFHLLPDKLRRER
LLRQNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAV
ITDGKYFSFFCYQLNTLALTTQADQNNPRKNICWGTQSKPLYETIEDNDV
KGFNDDVLLQIVHFLLNRPK

3D structure

PDB

8k2a Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

2.9 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Sf	A49 S50 A53 D54 S55 K56 A57 R59 R62 I63 W66 R81 K85 M86 Q87 M89 Y94 T97 F98 R162 H164 R165 Y166 R219 G220 H221 R222 R223 R225 F274 Q277 R310	A9 S10 A13 D14 S15 K16 A17 R19 R22 I23 W26 R41 K45 M46 Q47 M49 Y54 T57 F58 R102 H104 R105 Y106 R159 G160 H161 R162 R163 R165 F214 Q217 R250

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

	Biological Process
GO:0006915	apoptotic process
GO:0032543	mitochondrial translation

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005762	mitochondrial large ribosomal subunit
GO:0005840	ribosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8k2a, PDBe:8k2a, PDBj:8k2a
PDBsum	8k2a
PubMed	38942792
UniProt	Q9NP92\|RT30_HUMAN Large ribosomal subunit protein mL65 (Gene Name=MRPS30)

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