Structure of PDB 8xt2 Chain Sa

Receptor sequence
>8xt2Sa (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
PMKGRFPIRRTLQYLSQGNVVFKDSVKVMTVNYNTHGELGEGARKFVFFN
IPQIQYKNPWVQIMMFKNMTPSPFLRFYLDSGEQVLVDVETKSNKEIMEH
IRKILGKNEETLREEEEEKKQLSHPANFGPRKYCLRECICEVEGQVPCPS
LVPLPKEMRGKY
3D structure
PDB8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainSa
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Sa P2 M3 K4 G5 R6 R11 H37 P131 Y134 P150 S151 R160 P1 M2 K3 G4 R5 R10 H36 P130 Y133 P149 S150 R159
BS02 ZN Sa C141 C149 C140 C148
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum8xt2
PubMed38942792
UniProtP82663|RT25_HUMAN Small ribosomal subunit protein mS25 (Gene Name=MRPS25)

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