Structure of PDB 8xxn Chain SY

Receptor sequence

>8xxnSY (length=131) Species: 9606 (Homo sapiens) [Search protein sequence]

NDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTT
PDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKK
TSRKQRKERKNRMKKVRGTAKANVGAGKKPK

3D structure

PDB

8xxn Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

Chain

Resolution

3.6 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SY	R8 T9 R10 K11 F12 T14 G31 A33 T34 K37 M47 Y48 F58 G59 F60 R61 T62 F64 G65 G66 H89 R93 S103 R104 K105 R107 K108 K111 N112 K115 K116 G119 T120 A121 N124	R7 T8 R9 K10 F11 T13 G30 A32 T33 K36 M46 Y47 F57 G58 F59 R60 T61 F63 G64 G65 H88 R92 S102 R103 K104 R106 K107 K110 N111 K114 K115 G118 T119 A120 N123

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0031369	translation initiation factor binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0034101	erythrocyte homeostasis
GO:0042274	ribosomal small subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0044391	ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8xxn, PDBe:8xxn, PDBj:8xxn
PDBsum	8xxn
PubMed	38641729
UniProt	P62847\|RS24_HUMAN Small ribosomal subunit protein eS24 (Gene Name=RPS24)