Structure of PDB 8fkt Chain SY

Receptor sequence
>8fktSY (length=378) Species: 9606 (Homo sapiens) [Search protein sequence]
EEPFVLPPAGEMEQDAQAPDLQRVHKRIQDIVGILRDFGAQREEGRSRSE
YLNRLKKDLAIYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPVTLRTN
TLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPEYLAGH
YMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILAN
DANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSG
TGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYC
TCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPSLRS
TRRFYPHTHNMDGFFIAKFKKFSNSIPQ
3D structure
PDB8fkt Principles of human pre-60 S biogenesis.
ChainSY
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SY R257 S262 R263 D290 G452 R486 H489 K492 W526 Y530 K534 R538 R553 R555 E556 R558 H560 R42 S47 R48 D75 G237 R271 H274 K277 W311 Y315 K319 R323 R338 R340 E341 R343 H345
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0000470 maturation of LSU-rRNA
GO:0001510 RNA methylation
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0008284 positive regulation of cell population proliferation
GO:0032259 methylation
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0070475 rRNA base methylation
GO:1901796 regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fkt, PDBe:8fkt, PDBj:8fkt
PDBsum8fkt
PubMed37410842
UniProtP46087|NOP2_HUMAN 28S rRNA (cytosine(4447)-C(5))-methyltransferase (Gene Name=NOP2)

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