Structure of PDB 7qvp Chain SY

Receptor sequence

>7qvpSY (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]

DTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTP
DVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKT
SRKQRKERKNRMKKVRGTAKANV

3D structure

PDB

7qvp A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

Chain

Resolution

3.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SY	R8 T9 R10 K11 F12 T14 K32 A33 T34 V35 P36 K37 Y48 F58 G59 F60 R61 T62 H63 F64 G65 H89 R93 R104 K108 K111 N112 K115 K116 T120 K122	R6 T7 R8 K9 F10 T12 K30 A31 T32 V33 P34 K35 Y46 F56 G57 F58 R59 T60 H61 F62 G63 H87 R91 R102 K106 K109 N110 K113 K114 T118 K120

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0031369	translation initiation factor binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0034101	erythrocyte homeostasis
GO:0042274	ribosomal small subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0044391	ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7qvp, PDBe:7qvp, PDBj:7qvp
PDBsum	7qvp
PubMed	36302773
UniProt	P62847\|RS24_HUMAN Small ribosomal subunit protein eS24 (Gene Name=RPS24)