Structure of PDB 8xxl Chain SX

Receptor sequence

>8xxlSX (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]

GKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIV
LEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVL
VAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR

3D structure

PDB

8xxl Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

Chain

Resolution

2.9 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SX	G2 K3 C4 R5 G6 R8 T9 R11 K12 H16 R17 R18 Q20 K21 W22 H23 D24 K25 K28 T34 L36 A44 S45 H46 A47 K48 K60 Q61 N63 S64 A65 I66 R67 K68 K76 P86 N87 D88 L101 G104 G106 R107 K108 H110 V112 G113 D114 K121 K124 S129 L131 K137	G1 K2 C3 R4 G5 R7 T8 R10 K11 H15 R16 R17 Q19 K20 W21 H22 D23 K24 K27 T33 L35 A43 S44 H45 A46 K47 K59 Q60 N62 S63 A64 I65 R66 K67 K75 P85 N86 D87 L100 G103 G105 R106 K107 H109 V111 G112 D113 K120 K123 S128 L130 K136

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0034063	stress granule assembly
GO:0042274	ribosomal small subunit biogenesis
GO:1990145	maintenance of translational fidelity

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8xxl, PDBe:8xxl, PDBj:8xxl
PDBsum	8xxl
PubMed	38641729
UniProt	P62266\|RS23_HUMAN Small ribosomal subunit protein uS12 (Gene Name=RPS23)