Structure of PDB 8btk Chain SX

Receptor sequence
>8btkSX (length=425) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
FLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIM
SSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGD
TPKDRALFNGAQKLFGMIITIGQSIVYVMGICLLITIQLFVAGLIVLLLD
ELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIAL
FHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLP
IKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFPVGG
LCHYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDV
AKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGA
IGSGTGILLAVTIIYQYFEIFVKEQ
3D structure
PDB8btk Molecular basis of the TRAP complex function in ER protein biogenesis.
ChainSX
Resolution3.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SX K25 K268 R271 R273 G403 R405 K21 K252 R255 R257 G363 R365
BS02 peptide SX I19 P22 W34 V157 L168 I15 P18 W30 V141 L152
Gene Ontology
Molecular Function
GO:0005048 signal sequence binding
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
GO:0043022 ribosome binding
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0015031 protein transport
GO:0031204 post-translational protein targeting to membrane, translocation
GO:0039019 pronephric nephron development
GO:0045047 protein targeting to ER
GO:0045048 protein insertion into ER membrane
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005784 Sec61 translocon complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8btk, PDBe:8btk, PDBj:8btk
PDBsum8btk
PubMed37170030
UniProtP38377|S61A1_CANLF Protein transport protein Sec61 subunit alpha isoform 1 (Gene Name=SEC61A1)

[Back to BioLiP]