Structure of PDB 8xxn Chain SW

Receptor sequence

>8xxnSW (length=129) Species: 9606 (Homo sapiens)

VRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFE
IIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGF
IVLTTSAGIMDHEEARRKHTGGKILGFFF

3D structure

• PDB: 8xxn Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
• Chain: SW
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SW	V2 R3 M4 V6 N16 R20 K22 R28 K32 R57 K60 N70 K71 V74 I75 S76 R78 D80 Q82 K88 W89 T105 T106 S107 H120 G122 K124 F130	V1 R2 M3 V5 N15 R19 K21 R27 K31 R56 K59 N69 K70 V73 I74 S75 R77 D79 Q81 K87 W88 T104 T105 S106 H119 G121 K123 F129

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0008284 positive regulation of cell population proliferation
• GO:0009615 response to virus
• GO:0042274 ribosomal small subunit biogenesis
• GO:0045787 positive regulation of cell cycle

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8xxn, PDBe:8xxn, PDBj:8xxn
• PDBsum: 8xxn
• PubMed: 38641729
• UniProt: P62244|RS15A_HUMAN Small ribosomal subunit protein uS8 (Gene Name=RPS15A)