Structure of PDB 8xxl Chain SW

Receptor sequence

>8xxlSW (length=129) Species: 9606 (Homo sapiens) [Search protein sequence]

VRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFE
IIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGF
IVLTTSAGIMDHEEARRKHTGGKILGFFF

3D structure

PDB

8xxl Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

Chain

Resolution

2.9 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SW	V2 R3 M4 V6 A8 N16 K19 R20 R28 S31 K32 R57 A58 K60 K71 V74 I75 S76 R78 D80 Q82 L83 K88 W89 T105 T106 S107 H120 G122 K124 F130	V1 R2 M3 V5 A7 N15 K18 R19 R27 S30 K31 R56 A57 K59 K70 V73 I74 S75 R77 D79 Q81 L82 K87 W88 T104 T105 S106 H119 G121 K123 F129

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0008284	positive regulation of cell population proliferation
GO:0009615	response to virus
GO:0042274	ribosomal small subunit biogenesis
GO:0045787	positive regulation of cell cycle

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8xxl, PDBe:8xxl, PDBj:8xxl
PDBsum	8xxl
PubMed	38641729
UniProt	P62244\|RS15A_HUMAN Small ribosomal subunit protein uS8 (Gene Name=RPS15A)