Structure of PDB 8fky Chain SW

Receptor sequence
>8fkySW (length=448) Species: 9606 (Homo sapiens) [Search protein sequence]
AFEDTSFASLCNLVNENTLKAIKEMGFTNMTEIQHKSIRPLLEGRDLLAA
AKTGSGKTLAFLIPAVELIVKLRFMPRNGTGVLILSPTRELAMQTFGVLK
ELMTHHVHTYGLIMGGSNRSAEAQKLGNGINIIVATPGRLLDHMQNTPGF
MYKNLQCLVIDEADRILDVGFEEELKQIIKLLPTRRQTMLFSATQTRKVE
DLARISLKKEPLYVGVDDDKANATVDGLEQGYVVCPSEKRFLLLFTFLKK
NRKKKLMVFFSSCMSVKYHYELLNYIDLPVLAIHGKQKQNKRTTTFFQFC
NADSGTLLCTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGRGH
ALLILRPEELGFLRYLKQSKVPLSEFDFSWSKISDIQSQLEKLIEKNYFL
HKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALSFGFKVPPFVDL
3D structure
PDB8fky Principles of human pre-60 S biogenesis.
ChainSW
Resolution2.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SW K297 Y573 K577 K125 Y398 K402
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fky, PDBe:8fky, PDBj:8fky
PDBsum8fky
PubMed37410842
UniProtQ9NVP1|DDX18_HUMAN ATP-dependent RNA helicase DDX18 (Gene Name=DDX18)

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