Structure of PDB 8xxn Chain SU

Receptor sequence
>8xxnSU (length=103) Species: 9606 (Homo sapiens) [Search protein sequence]
IHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTR
KTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTI
ADA
3D structure
PDB8xxn Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
ChainSU
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SU R21 V29 K49 K51 G52 R55 M56 P57 T58 R66 K67 P69 C70 G71 E72 G73 S74 K75 T76 W77 R83 K86 R87 H92 R5 V13 K33 K35 G36 R39 M40 P41 T42 R50 K51 P53 C54 G55 E56 G57 S58 K59 T60 W61 R67 K70 R71 H76
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0097371 MDM2/MDM4 family protein binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:1901798 positive regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Cellular Component
External links
PDB RCSB:8xxn, PDBe:8xxn, PDBj:8xxn
PDBsum8xxn
PubMed38641729
UniProtP60866|RS20_HUMAN Small ribosomal subunit protein uS10 (Gene Name=RPS20)

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