Structure of PDB 8xsy Chain SU

Receptor sequence
>8xsySU (length=104) Species: 9606 (Homo sapiens) [Search protein sequence]
AIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITT
RKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVT
IADA
3D structure
PDB8xsy Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainSU
Resolution3.0 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SU R21 V29 K30 E33 K51 G52 P53 V54 R55 M56 P57 R66 K67 P69 C70 G71 E72 G73 S74 K75 T76 W77 R79 R83 H85 K86 R87 R6 V14 K15 E18 K36 G37 P38 V39 R40 M41 P42 R51 K52 P54 C55 G56 E57 G58 S59 K60 T61 W62 R64 R68 H70 K71 R72
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0097371 MDM2/MDM4 family protein binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:1901798 positive regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xsy, PDBe:8xsy, PDBj:8xsy
PDBsum8xsy
PubMed38942792
UniProtP60866|RS20_HUMAN Small ribosomal subunit protein uS10 (Gene Name=RPS20)

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