Structure of PDB 7zjw Chain ST

Receptor sequence

>7zjwST (length=206) Species: 9986 (Oryctolagus cuniculus)

GISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGG
NKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCI
VLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDE
RKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRK
IKARKG

3D structure

• PDB: 7zjw Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.
• Chain: ST
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	ST	R77 R92 K124 Q168 K170	R76 R91 K123 Q167 K169
BS02	rna	ST	G2 I3 R5 D6 H9 K10 R11 R12 K13 T14 Y21 H22 K23 K24 R25 K26 Y27 L29 R31 A33 A34 R41 R42 I43 H44 T45 R47 V48 R49 G50 K53 K54 Y55 R56 L58 N64 S66 T73 R74 K75 S86 K98 N99 R141 S142 K143 Y149 A176 R178 Q181 R184	G1 I2 R4 D5 H8 K9 R10 R11 K12 T13 Y20 H21 K22 K23 R24 K25 Y26 L28 R30 A32 A33 R40 R41 I42 H43 T44 R46 V47 R48 G49 K52 K53 Y54 R55 L57 N63 S65 T72 R73 K74 S85 K97 N98 R140 S141 K142 Y148 A175 R177 Q180 R183

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7zjw, PDBe:7zjw, PDBj:7zjw
• PDBsum: 7zjw
• PubMed: 35709277
• UniProt: Q5E958|RS8_BOVIN Small ribosomal subunit protein eS8 (Gene Name=RPS8)