Structure of PDB 8xxn Chain SS

Receptor sequence

>8xxnSS (length=145) Species: 9606 (Homo sapiens) [Search protein sequence]

MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADI
DLTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLA
NGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRT

3D structure

PDB

8xxn Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

Chain

Resolution

3.6 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SS	F28 K34 G35 V36 G37 R38 R39 Y40 W82 F83 N85 R86 Q87 K88 H120 R121 R124 H125 L129 R130 V131 R132 G133 Q134 H135 T136 K137 T138 T139 R141 R144 T145	F28 K34 G35 V36 G37 R38 R39 Y40 W82 F83 N85 R86 Q87 K88 H120 R121 R124 H125 L129 R130 V131 R132 G133 Q134 H135 T136 K137 T138 T139 R141 R144 T145

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8xxn, PDBe:8xxn, PDBj:8xxn
PDBsum	8xxn
PubMed	38641729
UniProt	P62269\|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)