Structure of PDB 8xt2 Chain SS

Receptor sequence
>8xt2SS (length=185) Species: 9606 (Homo sapiens) [Search protein sequence]
KDEPWKYLESEEYQERYGSRPVWADYRRNHKGGVPPQRTRKTCIRRNKVV
GNPCPICRDHKLHVDFRNVKLLEQFVCAHTGIIFYAPYTGVCVKQHKRLT
QAIQKARDHGLLIYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSGDPWYP
WYNWKQPPERELSRLRRLYQGHLQEESGPPPESMP
3D structure
PDB8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainSS
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SS N80 K82 G83 G84 V85 Q88 R89 R91 K92 R96 R97 Y220 N29 K31 G32 G33 V34 Q37 R38 R40 K41 R45 R46 Y169
BS02 ZN SS C94 C105 C108 C43 C54 C57
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0030054 cell junction
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum8xt2
PubMed38942792
UniProtQ9Y676|RT18B_HUMAN Small ribosomal subunit protein mS40 (Gene Name=MRPS18B)

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