Structure of PDB 8g6j Chain SS

Receptor sequence

>8g6jSS (length=148) Species: 9606 (Homo sapiens)

SLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADID
LTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLAN
GLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVS

3D structure

• PDB: 8g6j mRNA decoding in human is kinetically and structurally distinct from bacteria.
• Chain: SS
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SS	R24 K25 F28 G35 V36 G37 R38 R39 Y40 R55 W82 F83 N85 Q87 K88 Q97 L107 D110 H120 R121 R124 H125 L129 R130 V131 R132 G133 Q134 H135 T136 K137 T138 T139 G140 R141 R142 G143 R144 T145 V146	R23 K24 F27 G34 V35 G36 R37 R38 Y39 R54 W81 F82 N84 Q86 K87 Q96 L106 D109 H119 R120 R123 H124 L128 R129 V130 R131 G132 Q133 H134 T135 K136 T137 T138 G139 R140 R141 G142 R143 T144 V145
BS02	rna	SS	K116 R118	K115 R117
BS03	rna	SS	G147 V148	G146 V147

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0014069 postsynaptic density
• GO:0015935 small ribosomal subunit
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8g6j, PDBe:8g6j, PDBj:8g6j
• PDBsum: 8g6j
• PubMed: 37020024
• UniProt: P62269|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)