Structure of PDB 7nwi Chain SS

Receptor sequence

>7nwiSS (length=137) Species: 9986 (Oryctolagus cuniculus)

PEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKR
AGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDN
KLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRR

3D structure

• PDB: 7nwi Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
• Chain: SS
• Resolution: 3.13 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SS	R24 K25 F28 K34 V36 G37 R39 R55 W82 F83 N85 Q87 K88 D110 H120 H125 R130 V131 R132 G133 Q134 H135 T136 K137 T138 T139 R141 R142	R19 K20 F23 K29 V31 G32 R34 R50 W77 F78 N80 Q82 K83 D105 H115 H120 R125 V126 R127 G128 Q129 H130 T131 K132 T133 T134 R136 R137

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7nwi, PDBe:7nwi, PDBj:7nwi
• PDBsum: 7nwi
• PubMed: 34157102
• UniProt: G1TPG3|RS18_RABIT Small ribosomal subunit protein uS13 (Gene Name=RPS18)