Structure of PDB 5lks Chain SS

Receptor sequence

>5lksSS (length=150) Species: 9606 (Homo sapiens)

LVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDL
TKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANG
LDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK

3D structure

• PDB: 5lks Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
• Chain: SS
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SS	K25 F28 G35 V36 G37 R38 R39 Y40 R55 W82 F83 N85 Q87 R130 V131 R132 G133 Q134 H135 T136 K137 T139 R141 G143 R144 T145 V146 V148 K150 K151 K152	K23 F26 G33 V34 G35 R36 R37 Y38 R53 W80 F81 N83 Q85 R128 V129 R130 G131 Q132 H133 T134 K135 T137 R139 G141 R142 T143 V144 V146 K148 K149 K150

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0014069 postsynaptic density
• GO:0015935 small ribosomal subunit
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5lks, PDBe:5lks, PDBj:5lks
• PDBsum: 5lks
• PubMed: 27665925
• UniProt: P62269|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)