Structure of PDB 8xxn Chain SR

Receptor sequence
>8xxnSR (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]
MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKI
AGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDP
DTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV
3D structure
PDB8xxn Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
ChainSR
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SR M1 G2 R3 V4 R5 T6 K7 K10 K11 F28 S43 K44 K45 N48 H56 K59 R60 R63 V124 G125 M126 F128 K129 R132 M1 G2 R3 V4 R5 T6 K7 K10 K11 F28 S43 K44 K45 N48 H56 K59 R60 R63 V124 G125 M126 F128 K129 R132
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006413 translational initiation
GO:0034101 erythrocyte homeostasis
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xxn, PDBe:8xxn, PDBj:8xxn
PDBsum8xxn
PubMed38641729
UniProtP08708|RS17_HUMAN Small ribosomal subunit protein eS17 (Gene Name=RPS17)

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