BioLiP

>8flcSR (length=601) Species: 9606 (Homo sapiens) [Search protein sequence]

AHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYQIHRIRHFYMRKV
KFTQQNYHDRLSQILTDFPKLDDIHPFYADLMNILYDKDHYKLALGQINI
AKNLVDNVAKDYVRLMKYGDSLYRCKQLKRAALGRMCTVIKRQKQSLEYL
EQVRQHLSRLPTIDPNTRTLLLCGYPNVGKSSFINKVTRADVDVQPYAFT
TKSLFVGHMDYKYLRWQVVDTPGILDHPLEDRNTIEMQAITALAHLRAAV
LYVMDLSEQCGHGLREQLELFQNIRPLFINKPLIVVANKCDVKRIAELSE
DDQKIFTDLQSEGFPVIETSTLTEEGVIKVKTEACDRLLAHRVETKMKGN
KVNEVLNRLHLAIPTRRDDKERPPFIPEGVKKRERDLELEMGDDYILDLQ
KYWDLMNLSEKHDKIPEIWEGHNIADYIDPAIMKKLEELEKEEELRTAAG
EYDSVSESEDEEMLEIRQLAKQIREKKKLKILESKEKNTQGPRMPRTAKK
VQRTVLEKEMRSLGVDMDDKDDAHYAVQARRSRSITRKRTPRDVSGLRDV
KMVKKAKTMMKNAQKKMNRLGKKGEADRHVFDMKPKHLLSGKRKAGKKDR
R

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

K7 D20 L23 Q27 R28 T32 V33 I34 K36 H41 R42 Y47 R49 K50 L66 P70 K71 K93 L94 L96 Q98 N100 I101 L105 K118 S122 R125 K127 K130 R131 L134 G135 R136 C138 T139 R143 R155 T163 R190 A191 Y198 F200 K203 V207 H209 R216 I236 R399 K491 K494 I495 S498 K499 K501 N502 T503 Q504 R510 P574 R575 K588 M592 K594 Q597 N601 R611 D615 H620 K625 R626 K627 G629 K630 K631 D632 R633 R634

K6 D19 L22 Q26 R27 T31 V32 I33 K35 H40 R41 Y46 R48 K49 L65 P69 K70 K92 L93 L95 Q97 N99 I100 L104 K117 S121 R124 K126 K129 R130 L133 G134 R135 C137 T138 R142 R154 T162 R189 A190 Y197 F199 K202 V206 H208 R215 I235 R385 K477 K480 I481 S484 K485 K487 N488 T489 Q490 R496 P541 R542 K555 M559 K561 Q564 N568 R578 D582 H587 K592 R593 K594 G596 K597 K598 D599 R600 R601

BS03

GDP

N178 V179 G180 K181 S182 S183 V195 Q196 P197 N289 K290 S321 T322 L323

N177 V178 G179 K180 S181 S182 V194 Q195 P196 N288 K289 S320 T321 L322

Molecular Function

RNA binding

GTPase activity

protein binding

GTP binding

preribosome binding

	Biological Process
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001649	osteoblast differentiation
GO:0008156	negative regulation of DNA replication
GO:0008285	negative regulation of cell population proliferation
GO:0022408	negative regulation of cell-cell adhesion
GO:0030336	negative regulation of cell migration
GO:0031397	negative regulation of protein ubiquitination
GO:0033342	negative regulation of collagen binding
GO:0042254	ribosome biogenesis
GO:0042273	ribosomal large subunit biogenesis
GO:0050821	protein stabilization

Biological Process

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

GO:0000463

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GO:0001649

osteoblast differentiation

GO:0008156

negative regulation of DNA replication

GO:0008285

negative regulation of cell population proliferation

GO:0022408

negative regulation of cell-cell adhesion

GO:0030336

negative regulation of cell migration

GO:0031397

negative regulation of protein ubiquitination

GO:0033342

negative regulation of collagen binding

GO:0042254

ribosome biogenesis

GO:0042273

ribosomal large subunit biogenesis

GO:0050821

protein stabilization

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0048471	perinuclear region of cytoplasm

Cellular Component

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol