Structure of PDB 8xsy Chain SQ

Receptor sequence

>8xsySQ (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]

SKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLL
EPVLLLGKERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQKYVDE
ASKKEIKDILIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR

3D structure

PDB

8xsy Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

3.0 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SQ	K4 Q11 V12 F13 R15 K17 T18 V22 K26 K33 R37 E43 R69 R71 K73 G74 G75 G76 H77 A79 Q80 R117 R125 R126 C127 E128 S129 K130 K131 F132 G136 R138 A139 R140 Y141 Q142 K143 S144 Y145 R146	K2 Q9 V10 F11 R13 K15 T16 V20 K24 K31 R35 E41 R67 R69 K71 G72 G73 G74 H75 A77 Q78 R115 R123 R124 C125 E126 S127 K128 K129 F130 G134 R136 A137 R138 Y139 Q140 K141 S142 Y143 R144

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0042274	ribosomal small subunit biogenesis
GO:1990830	cellular response to leukemia inhibitory factor

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8xsy, PDBe:8xsy, PDBj:8xsy
PDBsum	8xsy
PubMed	38942792
UniProt	P62249\|RS16_HUMAN Small ribosomal subunit protein uS9 (Gene Name=RPS16)