Structure of PDB 8fkp Chain SO

Receptor sequence
>8fkpSO (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
IPGPVCKGKWKNKERILIFSSRGINFRTRHLMQDLRMLMPHSKADTKMDR
KDKLFVINEVCEMKNCNKCIYFEAKKKQDLYMWLSNSPHGPSAKFLVQNI
HTLAELKMTGNCLKGSRPLLSFDPAFDELPHYALLKELLIQIFSTPRYHP
KSQPFVDHVFTFTILDNRIWFRNFQIIEEDAALVEIGPRFVLNLIKIFQG
SFGGPTLYENPHYQSPNMHRRVIRSITAAKYREKQQVKDVQKLRKKEPKT
LLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKKRIYKRQRKMKQR
MDSGKTK
3D structure
PDB8fkp Principles of human pre-60S biogenesis
ChainSO
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SO R68 G69 I70 F72 K93 R96 K99 K122 K123 E151 L152 K284 R332 K333 R335 Y337 K338 R339 Q340 R341 R22 G23 I24 F26 K47 R50 K53 K76 K77 E105 L106 K238 R286 K287 R289 Y291 K292 R293 Q294 R295
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fkp, PDBe:8fkp, PDBj:8fkp
PDBsum8fkp
PubMed37410842
UniProtQ8TDN6|BRX1_HUMAN Ribosome biogenesis protein BRX1 homolog (Gene Name=BRIX1)

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