Structure of PDB 6ole Chain SO

Receptor sequence
>6oleSO (length=137) Species: 9606 (Homo sapiens) [Search protein sequence]
ISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKA
DRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQS
ALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL
3D structure
PDB6ole Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
ChainSO
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SO N38 D39 H43 G49 K50 E51 T52 R55 G59 M60 D65 R66 E68 R98 I135 P136 S137 D138 S139 T140 R141 K143 R146 R147 R149 R150 N24 D25 H29 G35 K36 E37 T38 R41 G45 M46 D51 R52 E54 R84 I121 P122 S123 D124 S125 T126 R127 K129 R132 R133 R135 R136
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006417 regulation of translation
GO:0030218 erythrocyte differentiation
GO:0030490 maturation of SSU-rRNA
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ole, PDBe:6ole, PDBj:6ole
PDBsum6ole
PubMed31160784
UniProtP62263|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)

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