Structure of PDB 8xsz Chain SM

Receptor sequence
>8xszSM (length=122) Species: 9606 (Homo sapiens) [Search protein sequence]
VMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVQASNCDEPM
YVKLVEALLAEHQINLIKVDDNKKLGEWVGLCKIDREGNPRKVVGCSCVV
VKDYGKESQAKDVIEEYFKCKK
3D structure
PDB8xsz Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainSM
Resolution3.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SM R33 G34 R36 E37 D57 E58 L91 C106 R23 G24 R26 E27 D47 E48 L81 C96
BS02 ZN SM I35 C108 I25 C98
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0043231 intracellular membrane-bounded organelle
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8xsz, PDBe:8xsz, PDBj:8xsz
PDBsum8xsz
PubMed38942792
UniProtP25398|RS12_HUMAN Small ribosomal subunit protein eS12 (Gene Name=RPS12)

[Back to BioLiP]