Structure of PDB 8fks Chain SM

Receptor sequence
>8fksSM (length=437) Species: 9606 (Homo sapiens) [Search protein sequence]
YITRNKARKKLQLSLADFRRLCILKGIYPHEPTFYLIKDIRFLLHEPIVN
KFREYKVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDA
LRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFMHYIIAARALRK
VFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTL
LGFVNFRLYQLLNLHYPPKLEGQGTYALDSESCMEKLAALSASLARVVVS
AQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWD
KSLCIGATYDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNARLL
LPVAEYFSGVQLPPHLSPFVTEKEGDYVPPEKLKLLALQRGKKREKYLYQ
KIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKAR
3D structure
PDB8fks Principles of human pre-60 S biogenesis.
ChainSM
Resolution2.88 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SM K26 R71 H75 R90 K10 R41 H45 R60
BS02 rna SM K91 R93 K94 K98 R106 N110 K61 R63 K64 K68 R76 N80
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0008283 cell population proliferation
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016020 membrane
GO:0030687 preribosome, large subunit precursor
GO:0070545 PeBoW complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fks, PDBe:8fks, PDBj:8fks
PDBsum8fks
PubMed37410842
UniProtO00541|PESC_HUMAN Pescadillo homolog (Gene Name=PES1)

[Back to BioLiP]