Structure of PDB 6xa1 Chain SM

Receptor sequence
>6xa1SM (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
DVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYV
KLVEALCAEHQINLIKVDDNKKLGEWVGLCRKVVGCSCVVVKDYGKESQA
KDVIEEYFKCKK
3D structure
PDB6xa1 Selective inhibition of human translation termination by a drug-like compound.
ChainSM
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SM R33 G34 I35 R36 E37 K40 Y61 C106 S107 R21 G22 I23 R24 E25 K28 Y49 C86 S87
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0043231 intracellular membrane-bounded organelle
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xa1, PDBe:6xa1, PDBj:6xa1
PDBsum6xa1
PubMed33009412
UniProtP25398|RS12_HUMAN Small ribosomal subunit protein eS12 (Gene Name=RPS12)

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