Structure of PDB 7qvp Chain SJ

Receptor sequence

>7qvpSJ (length=179) Species: 9606 (Homo sapiens)

PVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLA
KIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLK
IEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRL
DSQKHIDFSLRSPYGGGRPGRVKRKNAKK

3D structure

• PDB: 7qvp A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
• Chain: SJ
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SJ	P2 V3 A4 R5 S6 W7 V8 C9 R10 K11 T12 T15 R17 R18 P19 F20 R38 N39 K40 R41 R45 R79 R80 R83 K121 S122 H125 R127 R131 Q132 R133 H134 Q140 V142 N143 I144 S146 F147 I148 R150 S153 R162 P164 G171 R172 V173 K174 R175	P1 V2 A3 R4 S5 W6 V7 C8 R9 K10 T11 T14 R16 R17 P18 F19 R37 N38 K39 R40 R44 R78 R79 R82 K120 S121 H124 R126 R130 Q131 R132 H133 Q139 V141 N142 I143 S145 F146 I147 R149 S152 R161 P163 G170 R171 V172 K173 R174

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022627 cytosolic small ribosomal subunit
• GO:0043226 organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qvp, PDBe:7qvp, PDBj:7qvp
• PDBsum: 7qvp
• PubMed: 36302773
• UniProt: A0A6J0B498