Structure of PDB 8xt0 Chain SI

Receptor sequence
>8xt0SI (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
EDFIKKQIEEFNIGKRHLANMMGEDPETFTQEDIDRAIAYLFPSGLFEKR
ARPVMKHPEQIFPRQRAIQWGEDGRPFHYLFYTGKQSYYSLMHDVYGMLL
NLEKHQRWLIKEELEEMLVEKLSDLDYMQFIRLLEKLLTSQCGAAEEEFV
QRFRRSVTLESKKQLIEPVQYDEQGMAFSKSEGKRKTAKAEAIVYKHGSG
RIKVNGIDYQLYFPITQDREQLMFPFHFVDRLGKHDVTCTVSGGGRSAQA
GAIRLAMAKALCSFVTEDEVEWMRQAGLLTTDPRVRERKKPGQEGARRKF
TWKK
3D structure
PDB8xt0 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainSI
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SI F117 E118 K119 L216 D217 Q220 K277 T278 Q308 G336 S338 A339 R375 V376 R377 E378 K380 K381 P382 G383 A387 R388 R389 T392 K394 F47 E48 K49 L125 D126 Q129 K186 T187 Q217 G245 S247 A248 R284 V285 R286 E287 K289 K290 P291 G292 A296 R297 R298 T301 K303
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt0, PDBe:8xt0, PDBj:8xt0
PDBsum8xt0
PubMed38942792
UniProtP82933|RT09_HUMAN Small ribosomal subunit protein uS9m (Gene Name=MRPS9)

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