Structure of PDB 7qvp Chain SI

Receptor sequence

>7qvpSI (length=206) Species: 9606 (Homo sapiens) [Search protein sequence]

GISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGG
NKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCI
VLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDE
RKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRK
IKARKG

3D structure

PDB

7qvp A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SI	R77 N88 E89 R92 K124 K170	R76 N87 E88 R91 K123 K169
BS02	rna	SI	G2 I3 R5 N7 H9 K10 R11 R12 T14 K17 K19 Y21 H22 K23 K24 R25 K26 Y27 L29 G30 R31 A33 A34 R41 R42 I43 H44 T45 R47 V48 R49 G50 K54 Y55 R56 L58 N64 S66 T73 R74 K75 S86 N87 K98 N99 K140 R141 I145 K148 Y149 R178 Q181 C182 G183 R184 D186 G187	G1 I2 R4 N6 H8 K9 R10 R11 T13 K16 K18 Y20 H21 K22 K23 R24 K25 Y26 L28 G29 R30 A32 A33 R40 R41 I42 H43 T44 R46 V47 R48 G49 K53 Y54 R55 L57 N63 S65 T72 R73 K74 S85 N86 K97 N98 K139 R140 I144 K147 Y148 R177 Q180 C181 G182 R183 D185 G186

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0042274	ribosomal small subunit biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7qvp, PDBe:7qvp, PDBj:7qvp
PDBsum	7qvp
PubMed	36302773
UniProt	P62241\|RS8_HUMAN Small ribosomal subunit protein eS8 (Gene Name=RPS8)

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