Structure of PDB 7mqa Chain SI

Receptor sequence

>7mqaSI (length=803) Species: 9606 (Homo sapiens)

DQKKHRKKNSGPKAAKKKKRLLQDEEDARKRNPKAFAVQSAVRMARSFHR
TQDLKTKKHHIPVVDRTPLEPPPIVVVVMGPPKVGKSTLIQCLIRNFTRQ
KLTEIRGPVTIVSGKKRRLTIIECGCDINMMIDLAKVADLVLMLIDASFG
FEMETFEFLNICQVHGFPKIMGVLTHLDSFKHNKQLKKTKKRLKHRFWTE
VYPGAKLFYLSGMVHGEYQNQEIHNLGRFITVMKFRPLTWQTSHPYILAD
RMEDLTNPEDIRTNIKCDRKVSLYGYLRGAHLKNKSQIHMPGVGDFAVSD
ISFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGRQQQAAPNLRKLIYG
HKADSLDCSRFLVEAPHDWDLEEVMNSIRDCFVTESTYFDDLKGEMQKQA
QLNRAEFEDQDDEARVQYEGFRPGMYVRIEIENVPCEFVQNFDPHYPIIL
GGLGNSEGNVGYVQMRLKKHRWYKKILKSRDPIIFSVGWRRFQTIPLYYI
EDHNGRQRLLKYTPQHMHCGAAFWGPITPQGTGFLAIQSVSGIMPDFRIA
ATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFNSALEVAKFEGA
VIRTVSGIRGQIKKALRAPEGAFRASFEDKLLMSDIVFMRTWYPVSIPAF
YNPVTSLLKPVGEKDTWSGMRTTGQLRLAHGVRLKANKDSLYKPILRQKK
HFNSLHIPKALQKALPFKNKPKTQAKAGKVPKDRRRPAVIREPHERKILA
LLDALSTVHSQKMKKAKEQRHLHNKEHFRAKQKEEEEKLKRQKDLRKKLF
RIQ

3D structure

• PDB: 7mqa Nucleolar maturation of the human small subunit processome.
• Chain: SI
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SI	Q6 K7 K8 H9 R10 K12 N13 S14 P16 K17 K20 K21 R24 R40 N41 A44 F45 Q48 S49 V51 R52 M53 R55 S56 H58 R59 T60 K66 H69 V72 K178 H191 K193 Q194 K196 K197 K203 Y211 H233 N234 R237 F238 K243 R245 P246 K852 K934 I935 K937 I959 N963 R965 R967 L969 K970 Y971 H975 M976 K1026 K1028 F1037 K1038 N1039 T1040 R1062 V1064 R1068 K1072 K1073 R1076 R1083 E1087 D1088 K1089 L1091 R1099 S1149 Y1151 H1160 N1162 H1165 R1229 N1233 K1234 H1236 F1237 Q1241 R1260	Q2 K3 K4 H5 R6 K8 N9 S10 P12 K13 K16 K17 R20 R31 N32 A35 F36 Q39 S40 V42 R43 M44 R46 S47 H49 R50 T51 K57 H60 V63 K169 H182 K184 Q185 K187 K188 K194 Y202 H224 N225 R228 F229 K234 R236 P237 K393 K475 I476 K478 I500 N504 R506 R508 L510 K511 Y512 H516 M517 K567 K569 F578 K579 N580 T581 R603 V605 R609 K613 K614 R617 R624 E628 D629 K630 L632 R640 S690 Y692 H701 N703 H706 R770 N774 K775 H777 F778 Q782 R801
BS02	rna	SI	K7 L26 K1252	K3 L22 K793
BS03	GTP	SI	P91 K92 V93 G94 K95 S96 T97 H185 D187 M222 Y227	P82 K83 V84 G85 K86 S87 T88 H176 D178 M213 Y218
BS04	MG	SI	S96 E132	S87 E123

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0005525 GTP binding
• GO:0034511 U3 snoRNA binding

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0005730 nucleolus
• GO:0030686 90S preribosome
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:7mqa, PDBe:7mqa, PDBj:7mqa
• PDBsum: 7mqa
• PubMed: 34516797
• UniProt: Q14692|BMS1_HUMAN Ribosome biogenesis protein BMS1 homolog (Gene Name=BMS1)