Structure of PDB 8xxl Chain SH

Receptor sequence

>8xxlSH (length=186) Species: 9606 (Homo sapiens) [Search protein sequence]

SAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVG
GGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKP
TRKKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVH
LDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQ

3D structure

PDB

8xxl Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SH	V66 P67 R98 R99 K103 T105 R106 K111 N112 K113 Q114 K115 R116 P117 R118 S119 R120 T121 L122 T123 T181	V62 P63 R94 R95 K99 T101 R102 K104 N105 K106 Q107 K108 R109 P110 R111 S112 R113 T114 L115 T116 T174

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0048027	mRNA 5'-UTR binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0001843	neural tube closure
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0010628	positive regulation of gene expression
GO:0014033	neural crest cell differentiation
GO:0042274	ribosomal small subunit biogenesis
GO:0050821	protein stabilization
GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005856	cytoskeleton
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0032991	protein-containing complex
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8xxl, PDBe:8xxl, PDBj:8xxl
PDBsum	8xxl
PubMed	38641729
UniProt	P62081\|RS7_HUMAN Small ribosomal subunit protein eS7 (Gene Name=RPS7)

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