Structure of PDB 7qvp Chain SH

Receptor sequence

>7qvpSH (length=183) Species: 9606 (Homo sapiens) [Search protein sequence]

VKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRK
AIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKS
KNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDK
AQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQ

3D structure

PDB

7qvp A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SH	V66 R98 R99 R106 K107 S108 N112 Q114 K115 R116 R118 S119 R120 T121 L122 T123 K178 G182	V58 R90 R91 R98 K99 S100 N102 Q104 K105 R106 R108 S109 R110 T111 L112 T113 K168 G172

Gene Ontology

	Molecular Function
GO:0003730	mRNA 3'-UTR binding
GO:0003735	structural constituent of ribosome
GO:0019901	protein kinase binding
GO:0048027	mRNA 5'-UTR binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0001843	neural tube closure
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0010628	positive regulation of gene expression
GO:0014033	neural crest cell differentiation
GO:0042274	ribosomal small subunit biogenesis
GO:0050821	protein stabilization
GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005856	cytoskeleton
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0032040	small-subunit processome
GO:0032991	protein-containing complex
GO:0045202	synapse
GO:0098794	postsynapse
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7qvp, PDBe:7qvp, PDBj:7qvp
PDBsum	7qvp
PubMed	36302773
UniProt	P62082\|RS7_MOUSE Small ribosomal subunit protein eS7 (Gene Name=Rps7)

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