Structure of PDB 3j7r Chain SH

Receptor sequence
>3j7rSH (length=189) Species: 9823 (Sus scrofa) [Search protein sequence]
SAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVG
GGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKP
TRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLI
KVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQ
3D structure
PDB3j7r Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
ChainSH
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SH V66 P67 Q97 R99 P102 K103 R106 K107 S108 R109 T110 K111 Q114 K115 R116 P117 R118 R120 T121 L122 T123 T181 G182 V62 P63 Q93 R95 P98 K99 R102 K103 S104 R105 T106 K107 Q110 K111 R112 P113 R114 R116 T117 L118 T119 T177 G178
Gene Ontology
Molecular Function
GO:0003730 mRNA 3'-UTR binding
GO:0003735 structural constituent of ribosome
GO:0019901 protein kinase binding
GO:0048027 mRNA 5'-UTR binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0001843 neural tube closure
GO:0006364 rRNA processing
GO:0006412 translation
GO:0010628 positive regulation of gene expression
GO:0014033 neural crest cell differentiation
GO:0042274 ribosomal small subunit biogenesis
GO:0050821 protein stabilization
GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0032991 protein-containing complex
GO:0045202 synapse
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3j7r, PDBe:3j7r, PDBj:3j7r
PDBsum3j7r
PubMed24930395
UniProtA0A287A9Y6

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