Structure of PDB 6z6n Chain SG

Receptor sequence

>6z6nSG (length=237) Species: 9606 (Homo sapiens)

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVV
RISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGC
IVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKE
DDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTK
KNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSL

3D structure

• PDB: 6z6n Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
• Chain: SG
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SG	N4 S6 Q13 L15 S53 N56 Q59 Q65 G66 V67 L68 R72 R74 L75 L76 H81 C83 Y84 R85 R87 R88 T89 G90 R92 R94 K95 S96 V108 N110 R131 L133 G134 P135 K136 R137 S139 R140 K143 K149 R154 R159 L162 K164 K167 R170 K172 A173 P174 K175 Q177 R178 V180 R183 V184 L185 Q186 H187 K188 R189 R190 R191 I192 A193 K195 K196 R198 K201 Q227 K230 R231 L234 S235 L237	N4 S6 Q13 L15 S53 N56 Q59 Q65 G66 V67 L68 R72 R74 L75 L76 H81 C83 Y84 R85 R87 R88 T89 G90 R92 R94 K95 S96 V108 N110 R131 L133 G134 P135 K136 R137 S139 R140 K143 K149 R154 R159 L162 K164 K167 R170 K172 A173 P174 K175 Q177 R178 V180 R183 V184 L185 Q186 H187 K188 R189 R190 R191 I192 A193 K195 K196 R198 K201 Q227 K230 R231 L234 S235 L237

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019901 protein kinase binding

Biological Process

• GO:0000082 G1/S transition of mitotic cell cycle
• GO:0000278 mitotic cell cycle
• GO:0001890 placenta development
• GO:0002181 cytoplasmic translation
• GO:0002309 T cell proliferation involved in immune response
• GO:0006364 rRNA processing
• GO:0006412 translation
• GO:0006924 activation-induced cell death of T cells
• GO:0007369 gastrulation
• GO:0008284 positive regulation of cell population proliferation
• GO:0022605 mammalian oogenesis stage
• GO:0031929 TOR signaling
• GO:0033077 T cell differentiation in thymus
• GO:0042274 ribosomal small subunit biogenesis
• GO:0042593 glucose homeostasis
• GO:0043065 positive regulation of apoptotic process
• GO:0043066 negative regulation of apoptotic process
• GO:0048821 erythrocyte development

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0030425 dendrite
• GO:0032040 small-subunit processome
• GO:0036464 cytoplasmic ribonucleoprotein granule
• GO:0044297 cell body
• GO:0048471 perinuclear region of cytoplasm
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6z6n, PDBe:6z6n, PDBj:6z6n
• PDBsum: 6z6n
• PubMed: 32687489
• UniProt: P62753|RS6_HUMAN Small ribosomal subunit protein eS6 (Gene Name=RPS6)