Structure of PDB 6xa1 Chain SG

Receptor sequence

>6xa1SG (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVV
RISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGC
IVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKE
DDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTK
KNKEEAAEYAKLLAKRMKEAKEKRQEQI

3D structure

PDB

6xa1 Selective inhibition of human translation termination by a drug-like compound.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SG	K2 N4 S6 P8 Q13 L15 R31 S53 N56 K58 Q59 G60 Q65 G66 R72 R74 H81 C83 Y84 R87 R88 G90 R92 R94 K95 S96 S107 N110 R131 R132 L133 G134 K136 R137 S139 R140 K149 R154 R159 K160 L162 K164 K167 R170 A173 P174 K175 I176 Q177 R178 V180 R183 L185 Q186 H187 R189 R190 R191 I192 A193 K195 R198 T199 K201	K2 N4 S6 P8 Q13 L15 R31 S53 N56 K58 Q59 G60 Q65 G66 R72 R74 H81 C83 Y84 R87 R88 G90 R92 R94 K95 S96 S107 N110 R131 R132 L133 G134 K136 R137 S139 R140 K149 R154 R159 K160 L162 K164 K167 R170 A173 P174 K175 I176 Q177 R178 V180 R183 L185 Q186 H187 R189 R190 R191 I192 A193 K195 R198 T199 K201

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019901	protein kinase binding

	Biological Process
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001890	placenta development
GO:0002181	cytoplasmic translation
GO:0002309	T cell proliferation involved in immune response
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006924	activation-induced cell death of T cells
GO:0007369	gastrulation
GO:0008284	positive regulation of cell population proliferation
GO:0022605	mammalian oogenesis stage
GO:0031929	TOR signaling
GO:0033077	T cell differentiation in thymus
GO:0042274	ribosomal small subunit biogenesis
GO:0042593	glucose homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0048821	erythrocyte development

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0030425	dendrite
GO:0032040	small-subunit processome
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0044297	cell body
GO:0048471	perinuclear region of cytoplasm
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6xa1, PDBe:6xa1, PDBj:6xa1
PDBsum	6xa1
PubMed	33009412
UniProt	P62753\|RS6_HUMAN Small ribosomal subunit protein eS6 (Gene Name=RPS6)

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