Structure of PDB 6olf Chain SF

Receptor sequence
>6olfSF (length=189) Species: 9606 (Homo sapiens) [Search protein sequence]
DIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQ
CPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNA
IINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRN
IKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR
3D structure
PDB6olf Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
ChainSF
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SF A57 A58 K59 R60 K63 M78 H79 G80 R81 N82 N83 G84 K85 K86 L87 M88 I128 R145 N148 R159 F163 R164 N165 I166 I169 A42 A43 K44 R45 K48 M63 H64 G65 R66 N67 N68 G69 K70 K71 L72 M73 I113 R130 N133 R144 F148 R149 N150 I151 I154
BS02 MG SF F163 R164 F148 R149
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006450 regulation of translational fidelity
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6olf, PDBe:6olf, PDBj:6olf
PDBsum6olf
PubMed31160784
UniProtP46782|RS5_HUMAN Small ribosomal subunit protein uS7 (Gene Name=RPS5)

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