Structure of PDB 3j7r Chain SE

Receptor sequence

>3j7rSE (length=262) Species: 9823 (Sus scrofa)

ARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNR
LKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRL
IYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPD
PLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERH
PGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEE
RDKRLAAKQSSG

3D structure

• PDB: 3j7r Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
• Chain: SE
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	SE	A2 R3 G4 P5 K6 K7 H8 K10 V12 K16 M19 D21 K22 L23 F27 A28 P29 R30 T33 G34 P35 K37 L38 R49 G58 D59 M66 R77 K106 R108 F130 G132 K134 G135 V140 A144 R145 T146 R148 G186 A187 N188 H201 P202 A219 R240	A1 R2 G3 P4 K5 K6 H7 K9 V11 K15 M18 D20 K21 L22 F26 A27 P28 R29 T32 G33 P34 K36 L37 R48 G57 D58 M65 R76 K105 R107 F129 G131 K133 G134 V139 A143 R144 T145 R147 G185 A186 N187 H200 P201 A218 R239

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation
• GO:0008284 positive regulation of cell population proliferation
• GO:0042274 ribosomal small subunit biogenesis
• GO:0045727 positive regulation of translation

Cellular Component

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0036464 cytoplasmic ribonucleoprotein granule
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:3j7r, PDBe:3j7r, PDBj:3j7r
• PDBsum: 3j7r
• PubMed: 24930395
• UniProt: A0A287B771