Structure of PDB 8xt0 Chain SB

Receptor sequence
>8xt0SB (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
FNDKILNEPLKHSDFFNVKELFSVRSLFDARVHLGHKAGCRHRFMEPYIF
GSRLDHDIIDLEQTATHLQLALNFTAHMAYRKGIILFISRNRQFSYLIEN
MARDCGEYAHTRYFRGGMLTNARLLFGPTVRLPDLIIFLHTLNNIFEPHV
AVRDAAKMNIPTVGIVDTNCNPCLITYPVPGNDDSPLAVHLYCRLFQTAI
TRAKEKRQQVEALYRLQ
3D structure
PDB8xt0 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainSB
Resolution3.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna SB R147 R149 Y170 R172 G173 G174 T177 N178 L181 N201 I202 V207 R210 D211 R90 R92 Y113 R115 G116 G117 T120 N121 L124 N144 I145 V150 R153 D154
BS02 ZN SB H93 D224 D241 H36 D167 D184
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0032543 mitochondrial translation
GO:0061668 mitochondrial ribosome assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8xt0, PDBe:8xt0, PDBj:8xt0
PDBsum8xt0
PubMed38942792
UniProtQ9Y399|RT02_HUMAN Small ribosomal subunit protein uS2m (Gene Name=MRPS2)

[Back to BioLiP]