Structure of PDB 8fkz Chain SA

Receptor sequence

>8fkzSA (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]

ARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYA
VSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFA
PTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLV
VEDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQ
RRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWT
ESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALR
APRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDK
AAAAAAAL

3D structure

PDB

8fkz Principles of human pre-60 S biogenesis.

Chain

Resolution

3.04 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	SA	P51 A53 K195 M196	P48 A50 K192 M193
BS02	rna	SA	A4 R33 F39 T42 R45 K46 N47 R49 Q50 Y52 S55 E56 A58 Q61 S63 V73 A74 R75 I76 P77 R78 R80 G82 G83 T84 H85 R86 Q89 N94 M95 R97 G98 R100 M101 F102 A103 K106 W108 R109 R110 R114 N116 T117 T118 Q119 K120 R121 K140 K163 T164 K165 K172 K181 K182 Y184 R188 R190 A191 G192 K193 K195 M196 R197 N198 R199 R201 R204 R205 K219 R222 N223 N236 K239 P242 G243 H245 R268 K274 S275 R303 P305 R306 K307 R311 R312 K316 N321 L322 R323 K327 K333 M335 R336 R342 Q343 N346 K353	A1 R30 F36 T39 R42 K43 N44 R46 Q47 Y49 S52 E53 A55 Q58 S60 V70 A71 R72 I73 P74 R75 R77 G79 G80 T81 H82 R83 Q86 N91 M92 R94 G95 R97 M98 F99 A100 K103 W105 R106 R107 R111 N113 T114 T115 Q116 K117 R118 K137 K160 T161 K162 K169 K178 K179 Y181 R185 R187 A188 G189 K190 K192 M193 R194 N195 R196 R198 R201 R202 K216 R219 N220 N233 K236 P239 G240 H242 R265 K271 S272 R300 P302 R303 K304 R308 R309 K313 N318 L319 R320 K324 K330 M332 R333 R339 Q340 N343 K350
BS03	MG	SA	V54 M101	V51 M98

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8fkz, PDBe:8fkz, PDBj:8fkz
PDBsum	8fkz
PubMed	37410842
UniProt	P36578\|RL4_HUMAN Large ribosomal subunit protein uL4 (Gene Name=RPL4)

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