Structure of PDB 8t4s Chain S

Receptor sequence

>8t4sS (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]

LVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDL
TKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANG
LDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRT

3D structure

PDB

8t4s Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses.

Chain

Resolution

2.6 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	S	R24 K25 F28 K34 G35 V36 G37 R39 Y40 R55 W82 F83 N85 R86 Q87 K88 R108 H120 R121 R124 H125 L129 R130 V131 R132 G133 Q134 H135 T136 K137 T138 T139 G140 R141 R142 R144 T145	R22 K23 F26 K32 G33 V34 G35 R37 Y38 R53 W80 F81 N83 R84 Q85 K86 R106 H118 R119 R122 H123 L127 R128 V129 R130 G131 Q132 H133 T134 K135 T136 T137 G138 R139 R140 R142 T143

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8t4s, PDBe:8t4s, PDBj:8t4s
PDBsum	8t4s
PubMed	37733586
UniProt	P62269\|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)