Structure of PDB 8qfd Chain S

Receptor sequence

>8qfdS (length=176) Species: 9606 (Homo sapiens) [Search protein sequence]

MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQ
LKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDL
TTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKI
KFPLPHRVLRRQHKPRFTTKRPNTFF

3D structure

PDB

8qfd The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	S	K2 A3 S4 G5 R8 Q66 V67 F68 K70 P72 R87 Y94 R95 R98 R111 G114 A115 R116 H117 R118 R120 R139 H146 D147 S148 H156 R157 V158 R160 H163 P165 R166 T168 T169 K170 R171 P172 N173 T174 F175 F176	K2 A3 S4 G5 R8 Q66 V67 F68 K70 P72 R87 Y94 R95 R98 R111 G114 A115 R116 H117 R118 R120 R139 H146 D147 S148 H156 R157 V158 R160 H163 P165 R166 T168 T169 K170 R171 P172 N173 T174 F175 F176
BS02	rna	S	S42 Y46 S49 K53 K55 K56 S57 H122	S42 Y46 S49 K53 K55 K56 S57 H122

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8qfd, PDBe:8qfd, PDBj:8qfd
PDBsum	8qfd
PubMed	38383789
UniProt	Q02543\|RL18A_HUMAN Large ribosomal subunit protein eL20 (Gene Name=RPL18A)

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