Structure of PDB 8imy Chain S

Receptor sequence
>8imyS (length=498) Species: 9606 (Homo sapiens) [Search protein sequence]
AAAGAAATHLEVARGKRAALFFAAVAIVLGLPLWWKTTETYRASLPYSQI
SGLNALQLRLMVPVTVVKLPFTVVHEREIPLKYKMKIKCRFQKAYRRALS
VQEAEAMLDEPQEQAEGSLTVYVISESYIGPKRTAVVRGFNIIGRRIVQV
AQAMSLTEDVLAAALADHLPERRPLKSSLGYEITFSLLNPDPKSHDVYWD
IEGAVRRYVQPFLNALGAAGNFSVDSQILYYAMLGVNPRFDSASSSYYLD
MHSLPHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPV
ATNAFHSPRWGGIMVYNVDSKTYNASVLPVRVEVDMVRVMEVFLAQLRLL
FGIAQPQLPPKCLLSGPTSEGLMTWELDRLLWARSVENLATATTTLTSLA
QLLGKISNIVIKDDVASEVYKAVAAVQKSAEELASGHLASAFVASQEAVT
SSELAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLVKIFLET
3D structure
PDB8imy Structures of substrates- and products-bound glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis
ChainS
Resolution3.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LBN S I28 G31 W35 W36 T39 Y522 I523 F526 A530 I27 G30 W34 W35 T38 Y476 I477 F480 A484
BS02 80T S R15 R18 R14 R17
BS03 6OU S P33 K37 P32 K36
BS04 Y01 S R18 L21 F22 R17 L20 F21
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006506 GPI anchor biosynthetic process
GO:0008218 bioluminescence
GO:0016255 attachment of GPI anchor to protein
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0042765 GPI-anchor transamidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8imy, PDBe:8imy, PDBj:8imy
PDBsum8imy
PubMed37684232
UniProtQ96S52|PIGS_HUMAN GPI transamidase component PIG-S (Gene Name=PIGS)

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