Structure of PDB 8imx Chain S

Receptor sequence
>8imxS (length=513) Species: 9606 (Homo sapiens) [Search protein sequence]
AAAGAAATHLEVARGKRAALFFAAVAIVLGLPLWWKTTETYRASLPYSQI
SGLNALQLRLMVPVTVVFTKLPFTVVHEREIPLKYKMKIKCRFQKAYRRA
LDVQEAEAMLDEPQEQAEGSLTVYVISEHSSLLPQDMMSYIGPKRTAVVR
GAFNIIGRRIVQVAQAMSLTEDVLAAALADHLPEEKRRPLKSSLGYEITF
SLLNPDPKSHDVYWDIEGAVRRYVQPFLNALGAAGNFSVDSQILYYAMLG
VNPRFDSASSSYYLDMHSLPHVINPVESRLGSSAASLYPVLNFLLYVPEL
AHSPLYIQDKDGAPVATNAFHSPRWGGIMVYNVDSKTYNASVLPVRVEVD
MVRVMEVFLAQLRLLFGIAQPQLPPKCLLSGPTSEGLMTWELDRLLWARS
VENLATATTTLTSLAQLLGKISNIVIKDDVASEVYKAVAAVQKSAEELAS
GHLASAFVASQEAVTSSELAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAV
PILLSLVKIFLET
3D structure
PDB8imx Structures of substrates- and products-bound glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis
ChainS
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide S Q517 F519 A520 L527 P528 V531 Q486 F488 A489 L496 P497 V500
BS02 LBN S I28 G31 W35 W36 T39 K518 F519 F526 M529 I27 G30 W34 W35 T38 K487 F488 F495 M498
BS03 80T S R15 R18 L21 F22 A25 R14 R17 L20 F21 A24
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006506 GPI anchor biosynthetic process
GO:0008218 bioluminescence
GO:0016255 attachment of GPI anchor to protein
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0042765 GPI-anchor transamidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8imx, PDBe:8imx, PDBj:8imx
PDBsum8imx
PubMed37684232
UniProtQ96S52|PIGS_HUMAN GPI transamidase component PIG-S (Gene Name=PIGS)

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