Structure of PDB 8crx Chain S

Receptor sequence
>8crxS (length=60) Species: 1747 (Cutibacterium acnes) [Search protein sequence]
AKTALKVKAARKPKFGVRAYTRCQRCGRPHSVYRKFGLCRICLREMAHAG
QLPGVTKSSW
3D structure
PDB8crx Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
ChainS
Resolution2.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna S A2 K3 T4 A5 L6 K9 K15 F16 V18 R19 Y21 R23 C27 R29 H31 S32 V33 R35 R41 I42 R45 K58 S60 W61 A1 K2 T3 A4 L5 K8 K14 F15 V17 R18 Y20 R22 C26 R28 H30 S31 V32 R34 R40 I41 R44 K57 S59 W60
BS02 ZN S C24 C27 C40 C43 C23 C26 C39 C42
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008270 zinc ion binding
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Cellular Component
External links
PDB RCSB:8crx, PDBe:8crx, PDBj:8crx
PDBsum8crx
PubMed36864821
UniProtA0A2B7JMX1

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