Structure of PDB 8bea Chain S

Receptor sequence
>8beaS (length=449) Species: 9606 (Homo sapiens) [Search protein sequence]
MRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYH
MYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPAELKRFRKEYIQP
VQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESIT
KIIQRKKIFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDL
YRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENL
EERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPS
RQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNP
EVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLN
PMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN
3D structure
PDB8bea Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
ChainS
Resolution2.47 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide S M878 Y884 F890 K898 L901 E902 H905 E906 E909 M283 Y289 F295 K303 L306 E307 H310 E311 E314
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8bea, PDBe:8bea, PDBj:8bea
PDBsum8bea
PubMed37067463
UniProtQ07889|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

[Back to BioLiP]